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Up Directory CCL 23.12.12 Streamlining the design of PROTACs® and PROTAC linkers Webinar, Online
From: chemistry-request at
To: chemistry-request at
Date: Tue Nov 21 06:06:55 2023
Subject: 23.12.12 Streamlining the design of PROTACs® and PROTAC linkers Webinar, Online
Register here -

Date: Tuesday 12th December, 2023
Time: 2pm GMT / 3pm CET / 9am EST / 6:30pm IST
Duration: 45 minutes

A high percentage of pharmaceutical targets are undruggable by small 
molecules. To address this issue, researchers have recently turned to 
Proteolysis Targeting Chimeras (PROTACs). PROTACs are bifunctional molecules 
that aim to mark a protein of interest for protein degradation, wherein a 
target-binding ligand and a ligase-binding ligand are connected via a linker. 
This system allows the target protein to be tagged for protein degradation by 
a proteosome complex. However, the design of PROTACs can be quite challenging, 
including the search for novel linkers, the optimization of linker properties, 
and the prediction of how the PROTAC will bind to the protein complex.

In this webinar, we will explore PROTACs and demonstrate how software solutions
 Spark and Flare can help overcome some of these challenges and streamline 
the design of PROTACs and PROTAC linkers. By attending the webinar, you will 
learn how to:

- Modify your existing linkers with Spark's scaffold hopping experiment and 
  Flare's Hit Expander module
- Find novel linkers with Spark's ligand joining experiment
- Create custom Spark linker libraries with Flare
- Synthesize your PROTAC complexes with Flare's Library Enumeration feature
- Dock your PROTACs to binary protein complexes and assess their fit to the 
  protein binding sites
- Use Flare's unique Electrostatic Complementarity feature to visually and 
  numerically assess the complementarity of PROTACs to the binding sites in 
  the protein complex

Register here -
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