QSAR - Life Sciences News Update

From: Bio.com / Bio Online <newsletter[A]bio.com>
Date: Tue, 16 Jul 2002 03:59:50 -0700 (PDT)

Bio.com Life Sciences News Update
July 16, 2002

Produced by Bio Online(r)
Portal to the Life Sciences(tm)
www.bio.com | www.bioprotocol.com

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CONTENTS:
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1. Science News: "New Strategy for AIDS Vaccine"
2. InFocus: "Pharmacogenomics" - Transcript and mp3 now available
3. Career Center: The "Next Generation" Career Center is here
4. Jobs of the Week: "Staff Scientist" and others
5. Market Research: "C.H.I. Patent Profiles"
6. Featured Software: "HyperChem Release 7.01" and others

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Newsletter Sponsored by: Applied Biosystems
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1. SCIENCE NEWS
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-Crucial Chromatin-Modifying Enzyme Discovered
http://www.bio.com/Redirectors/LinkRedirect7_15.jhtml?link=1
Over the past few years, covalent modifications of histone tails have
emerged as an important mechanism of gene regulation in eukaryotes. Now,
scientists have identified a major euchromatic histone methyltransferase
in mammalian cells that is crucial for normal embryonic development, and
possibly the prevention of cancer.

-New Strategy for AIDS Vaccine
http://www.bio.com/Redirectors/LinkRedirect7_15.jhtml?link=2
In an article appearing recently in the journal Science, a team of Los
Alamos researchers - in conjunction with researchers from Duke University,
Harvard School of Public Health and the University of Alabama - suggests
using a consensus or genetic ancestor of the HIV-1 virus when developing
vaccines, rather than basing vaccines on geographically specific strains of
the virus.

-Antioxidant-Rich Diets Protect the Brain
http://www.bio.com/Redirectors/LinkRedirect7_15.jhtml?link=3
Popeye was right - eat your spinach. In fact, add some fresh-cut apples to
that spinach salad. Two new animal studies by researchers at the University
of South Florida Center for Aging and Brain Repair and James A. Haley
Veterans Hospital bolster a growing body of evidence that certain fruits and
vegetables may protect the brain against the ravages of age.

-Viruses Help Strep Bacteria Turn Deadly
http://www.bio.com/Redirectors/LinkRedirect7_15.jhtml?link=4
A common bacterium can turn into a potent killer if it picks up the right
set of genes, but how and when those genes are acquired has remained poorly
understood. In a new study, researchers show that special viruses are the
culprits behind the emergence of virulent select new bacterial strains.

-Improved Web Site to Study Genes
http://www.bio.com/Redirectors/LinkRedirect7_15.jhtml?link=5
A group of researchers have designed a Web site that provides an easier and
more accurate way to search for potential disease-causing genes. The new
site, known as SAGE Genie, is available online as part of the Cancer Genome
Anatomy Project run by the National Cancer Institute (NCI).

-Making Sense of Marfan Syndrome
http://www.bio.com/Redirectors/LinkRedirect7_15.jhtml?link=6
In the July 15 issue of Genes & Development, researchers from Johns Hopkins
University report on their determination of a molecular mechanism of Marfan
syndrome pathogenesis - a discovery that may end the decade-long debate over
how this relatively common genetic disorder develops.

-FEATURE: Featured Molecule: p53 Tumor Suppressor
http://www.bio.com/Redirectors/LinkRedirect7_15.jhtml?link=7
Our cells face many dangers, including chemicals, viruses, and ionizing
radiation. If key regulatory elements are damaged, the normal controls on
cell growth may be blocked and the cell will rapidly multiply and grow into
a tumor. p53 tumor suppressor is one of our defenses against this type of
damage. p53 tumor suppressor is normally found at low levels, but when DNA
damage is sensed, p53 levels rise and initiate protective measures...

-FEATURE: An Airbus Could Tiptoe On Spider Silk
http://www.bio.com/Redirectors/LinkRedirect7_15.jhtml?link=8
A very specific type of spider silk - dragline silk - has been very popular
in the last decade. Dragline silk is the thread spiders use to make the
scaffolding of their webs and the thread from which they hang. Why is this
specific type of silk so popular? It is actually one of the toughest
materials known, which is surprising really when the flick of a feather
duster is sufficient to whip a web off the ceiling.

To view Industry news, visit:
http://www.bio.com/industryanalysis/industryanalysis_news.jhtml

To view Research news, visit:
http://www.bio.com/newsfeatures/newsfeatures_research.jhtml

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2. INFOCUS WEBCAST
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1) "Pharmacogenomics: Applications in Drug Development"
Broadcast Wednesday, July 10, 2002

*Click here to view the PDF transcript:
http://www.bio.com/file_temp/pharmacogenomics02.pdf

*Click here to listen to the audio recording:
http://chat.bio.com:8000/audio/pharmacogenomics_071002.mp3

*Click here to enter a drawing for a giveaway from our sponsors:
http://www.bio.com/Redirectors/LinkRedirect7_15.jhtml?link=9

*To view all past InFocus Webcast recordings and transcripts, go to:
http://www.bio.com/newsfeatures/newsfeatures_fochives.jhtml

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3. CAREER CENTER
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Tired of searching for jobs day after day?

Let Bio.com do the job search for you!

Bio.com works on behalf of selected employers in the life sciences industry to
look for top candidates like you. It's a personalized service that ensures:

-You will ONLY be contacted for positions that FIT your background.
-Strict Confidentiality: Unlike other sites that allow recruiters full access to
their resume database, Bio.com will maintain your anonymity until you choose to
be contacted by any given employer.

As a Bio.com Member, you will also enjoy Bio.com's new Career Center Tool
that allows you to:

-Gain access to thousands of life sciences job opportunities
(http://www.bio.com/careercenter/seekers/jobs_by_employer.jhtml)
-Receive Job Agent alerts for jobs that match your criteria
-Apply for jobs with a one click application process
-Maintain/store your resume confidentially
-Receive monthly e-newsletter with "Featured Jobs" and "Featured Employers"

These services are FREE for you to use. So, what are you waiting for?

Sign up for your Bio.com Membership and start your job search today!
http://www.bio.com/careercenter/index.jhtml

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4. JOBS OF THE WEEK
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Look at what's new in the Bio.com Career Center this week:

1. Setren Smallberg & Associates: Staff Scientist
http://www.bio.com/careercenter/seekers/view_job.jhtml?id=7300031

2. Women First Healthcare: Sales Analyst
http://www.bio.com/careercenter/seekers/view_job.jhtml?id=7400033

3. UC Riverside: Proteomics Coordinator (PhD position)
http://www.bio.com/careercenter/seekers/view_job.jhtml?id=5500010

4. Guava Technologies: Scientist, R&D Applications and Technical Support
http://www.bio.com/careercenter/seekers/view_job.jhtml?id=7200031

5. Setren, Smallberg & Associates: Sr. Research Associate
http://www.bio.com/careercenter/seekers/view_job.jhtml?id=7200031

6. Theravance, Associate Director: Financial Planning and Analysis
http://www.bio.com/careercenter/seekers/view_job.jhtml?id=8300021

Register today and start using our new features:
http://www.bio.com/careercenter/seekers/index.jhtml

Click here to browse all jobs from Bio.com's Career Center:
http://www.bio.com/careercenter/seekers/jobs_by_employer.jhtml

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5. MARKET RESEARCH
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Bio.com offers the most comprehensive collection of market research.

-C.H.I. Patent Profiles
http://www.bio.com/Redirectors/LinkRedirect7_15.jhtml?link=10
CHI Research, Inc. is a worldwide leader in Intellectual Property
consulting. Their analysts are recognized leaders in their field, and their
databases of patents are unparalleled in their accuracy. No other
Intellectual Property consulting firm can match the level of detail in CHI's
technology evaluations. These patent profiles offer concise, actionable
intelligence on the technological strengths and weaknesses of companies,
government agencies, academic institutions, and nonprofit organizations.
One of the fundamental drivers of a company's future success is the quality
of its technology. C.H.I. Patent Profiles provide unique quantitative
measures of that quality, allowing one company to be compared with
competitors over time and technology-by-technology.

-New Developments in Therapeutic Enzyme Inhibitors and Blockers
http://www.bio.com/Redirectors/LinkRedirect7_15.jhtml?link=11
This in-depth study analyzes commercial developments in small-molecule
therapeutic enzyme inhibitors and receptor blockers. This $121 billion
market is undergoing rapid change as new technologies such as genomics,
proteomics, high-throughput screening, rational drug design, and
combinatorial chemistry are being integrated into drug development and
discovery. Pharmaceutical and biotechnology companies working in the field
will find the report useful in that it provides an unbiased assessment of
the market potential of these compounds. Investors will find the report
particularly interesting, since it is rare to find a neutral appraisal of
future prospects for the drug industry.

-DNA Microarray Informatics: Key Technological Trends and Commercial
Opportunities
http://www.bio.com/Redirectors/LinkRedirect7_15.jhtml?link=12
This report is ideal for those seeking to maximize results from DNA
microarray studies, or for anyone who must understand the key trends and
technologies shaping this market. The report focuses on the data researchers
get from these powerful instruments, the best approaches to analyzing and
managing these data, and the challenge of designing experiments that yield
statistically defensible results. The report describes leading commercial
and academic software, as well as emerging breakthrough techniques.

Click here to browse through our publications catalogue:
http://www.bio.com/store/store_publications.jhtml

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6. FEATURED SOFTWARE
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Bio.com offers a very comprehensive selection of Life Science related
software. Check out these latest additions:

-HyperChem Release 7.01
http://www.bio.com/Redirectors/LinkRedirect7_15.jhtml?link=13
HyperChem is a sophisticated molecular modeling environment that is known
for its quality, flexibility, and ease of use. Uniting 3D visualization and
animation with quantum chemical calculations, molecular mechanics, and
dynamics, HyperChem puts more molecular modeling tools at your fingertips
than any other Windows program. The newest version, HyperChem Release 7.01,
is a full 32-bit application, developed for the Windows 95, 98, NT, ME, 2000
and XP operating systems. HyperChem Release 7.01 incorporates even more
powerful computational chemistry tools than ever before, as well as newly
incorporated modules, additional basis sets, new drawing capabilities and
more.

-FreezerWorks 5.2
http://www.bio.com/Redirectors/LinkRedirect7_15.jhtml?link=14
A major upgrade of the popular Freezerworks and CLIP sample tracking and
freezer inventory software. Both programs are now combined in Freezerworks
5.2, a powerful Windows, Macintosh, and NT based system. Whether storing
samples for long or short term, Freezerworks 5.2 improves on a popular
program known to save busy clinical and research laboratories and
repositories two or more hours a day previously spent searching for samples.

-Protein Tools
http://www.bio.com/Redirectors/LinkRedirect7_15.jhtml?link=15
The Protein Tools Software Package was designed for all biochemists working
with proteins and peptides. The package consists of three parts: a main
Protein Tools sequence editor, amino acid analysis software - AAA Fit, and
pI Calculation application that can help to predict the isoelectric point of
a designed protein. Protein Tools helps to interpret and organize data in an
orderly and clear fashion.

Click here to browse through our software catalogue:
http://www.bio.com/store/store_software.jhtml

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Copyright (c) 2002 Bio Online, Inc. All rights reserved.
Received on 2002-07-16 - 06:49 GMT

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