Bio.com Life Sciences News Update
August 14, 2002
Produced by Bio Online(r)
Portal to the Life Sciences(tm)
www.bio.com | www.bioprotocol.com
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CONTENTS:
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1. Science News: "Experimental Drug Slows Tumor Growth"
2. InFocus: "Cellular Signaling" - Listen to what the experts have to say
3. Featured Event: "World Genomics Symposium"
4. Career Center: The "Next Generation" Career Center is here
5. Jobs of the Week: "Senior Research Associate" and others
6. Market Research: "DNA Microarrays" and others
7. Featured Software: "BrainMaker Professional" and others
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Newsletter Sponsored by: IBM Life Sciences
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IBM's portfolio of data management (DM) solutions for the life sciences
includes DB2(r) Universal Database. DB2 has the capabilities you need for
research. Example: cost effectiveness: IBM's DB2 software licensing,
support and upgrade charges are more affordable than Oracle. For supporting
documentation/free quote on DB2 for the life sciences or to order a free
data management CD go to http://www.ibm.com/solutions/lifesciences/r/db2e45
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1. SCIENCE NEWS
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-Experimental Drug Slows Tumor Growth
http://www.bio.com/jump.jhtml?id=200001
One key weapon in the arsenal of new cancer therapies is called Herceptin,
a drug that is currently used to treat breast cancer and works by
targeting a specific protein called HER-2/neu. But despite the drug's
effectiveness, tumors shrink in only the small percentage of breast cancer
patients whose cancer cells express an over-abundance of HER-2/neu. Now,
researchers have found that a potent experimental drug called 2C4 slows
tumor growth in both breast and prostate cancer tumors in mice even when
small amounts of HER-2/neu are expressed.
-Subtract a Gene and Feasting Mice Add No Fat
http://www.bio.com/jump.jhtml?id=200002
By subtracting a single gene from the genome of a mouse, scientists have
created an animal that can eat a rich, high-fat diet without adding
weight or risking the complications of diabetes, according to a new study
published this week.
-Protein Map of "World's Toughest Bacterium"
http://www.bio.com/jump.jhtml?id=200003
Scientists at the Department of Energy's Pacific Northwest National
Laboratory have obtained the most complete protein coverage of any
organism to date with the study of a radiation-resistant microbe known to
survive extreme environments. This research potentially could open up new
opportunities to harness this microorganism, called Deinococcus radiodurans,
for bioremediation.
-Mutations that Cause Resistance to Gleevec
http://www.bio.com/jump.jhtml?id=200004
Researchers have identified specific mutations in a rogue gene that render
the drug Gleevec ineffective in some patients who have chronic myeloid
leukemia. The studies could provide new information that may improve the
effectiveness of second-generation drugs for chronic myeloid leukemia.
Gene Linked to Leukemia in Down's Patients
http://www.bio.com/jump.jhtml?id=200005
Researchers from the University of Chicago have identified a gene defect
that causes the development of leukemia in children with Down syndrome.
"This study, for the first time, defines a part of the molecular pathway
leading to acute megakaryoblastic leukemia," said John Crispino, Ph.D.,
director of the study. The discovery could speed diagnosis and provide a
new target for therapy.
-FEATURE: Legislating a Transgenics Revolution
http://www.bio.com/jump.jhtml?id=200006
Microsoft Chairman Bill Gates has said that the computer revolution is
unfolding at an exponential rate, but with respect to genetically engineered
plants and animals, there are many reasons to think we are on the eve of a
biotechnological revolution that will unfold even faster. How can that be?
To view Industry news, visit:
http://www.bio.com/jump.jhtml?id=200007
To view Research news, visit:
http://www.bio.com/jump.jhtml?id=200008
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2. INFOCUS WEBCAST
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1) "Cellular Signaling"
Broadcast Thursday, August 1, 2002
*Click here to listen to the audio recording:
http://www.bio.com/jump.jhtml?id=200030
*Click here to enter a drawing for a giveaway from our sponsors:
http://www.bio.com/jump.jhtml?id=200028
*To view all past InFocus Webcast recordings and transcripts, go to:
http://www.bio.com/jump.jhtml?id=200029
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3. FEATURED EVENT: WORLD GENOMICS SYMPOSIUM
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Join over 2,000 life science colleagues at World Genomics Symposium
and Exposition, September 18-20, 2002 at the new Atlantic City
Convention Center. Register at http://www.world-genomics.com for
FREE Expo and Poster Presentation admittance when you enter
priority code BIO2 before September 7. Same Priority Code gets
you $50 off Conference Admittance in a 60+ session program!
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4. CAREER CENTER
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Tired of searching for jobs day after day?
Let Bio.com do the job search for you!
Bio.com works on behalf of selected employers in the life sciences industry to
look for top candidates like you. It's a personalized service that ensures:
-You will ONLY be contacted for positions that FIT your background.
-Strict Confidentiality: Unlike other sites that allow recruiters full
access to their resume database, Bio.com will maintain your anonymity until
you choose to be contacted by any given employer.
As a Bio.com Member, you will also enjoy Bio.com's new Career Center Tool
that allows you to:
-Gain access to thousands of life sciences job opportunities
(http://www.bio.com/jump.jhtml?id=200009)
-Receive Job Agent alerts for jobs that match your criteria
-Apply for jobs with a one click application process
-Maintain/store your resume confidentially
-Receive monthly e-newsletter with "Featured Jobs" and "Featured Employers"
These services are FREE for you to use. So, what are you waiting for?
Sign up for your Bio.com Membership and start your job search today!
http://www.bio.com/jump.jhtml?id=200010
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5. JOBS OF THE WEEK
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Look at what's new in the Bio.com Career Center this week:
1. Affymetrix: Staff Scientist
http://www.bio.com/jump.jhtml?id=200011
2. Amphastar Pharmaceuticals: Regulatory Manager/Director
http://www.bio.com/jump.jhtml?id=200012
3. Setren Smallberg & Associates: Process Development Scientist
http://www.bio.com/jump.jhtml?id=200013
4. Eurogentec: Key Account Manager
http://www.bio.com/jump.jhtml?id=200014
5. Celera Genomics: Scientist
http://www.bio.com/jump.jhtml?id=200015
6. The Impact Group: Managing Editor
http://www.bio.com/jump.jhtml?id=200016
Register today and start using our new features:
http://www.bio.com/jump.jhtml?id=200017
Click here to browse all jobs from Bio.com's Career Center:
http://www.bio.com/jump.jhtml?id=200018
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6. MARKET RESEARCH
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Bio.com offers the most comprehensive collection of market research.
-The U.S. Generic Prescription Drug Industry
http://www.bio.com/jump.jhtml?id=200019
The aim of this report is to provide a range of information--from
detailed market analyses through industry trends--to quantify and qualify
the market for prescription generic drugs. Forecasts and trends are
gleaned from industry sources as well as from considered assessment of the
legislative environment, healthcare policies, demographics, and other
factors that directly affect the generic drug market. The report develops
forecasts for the generic drug market for major therapeutic categories
through 2006 and also examines strategies employed by generics-only
companies to meet the challenges of this highly competitive market.
-DNA Microarrays
http://www.bio.com/jump.jhtml?id=200020
Given their power, sensitivity and high-throughput capabilities, it is
reasonable to predict that DNA microarrays will play an increasingly
important role in drug discovery, development and evaluation. However,
the technology is new and both manufacturers and end-users are currently
trying to identify and optimize combinations of genes to be arrayed, in
addition to developing the best tools for data acquisition and analysis.
The Tools & Techniques of Drug Discovery takes an in-depth look at six
different market segments through the eyes of a worldwide panel of
pharmaceutical researchers. Based on a 36-question survey of over 150
qualified scientists, DNA Microarrays is the third of six titles in the
series, and specifically examines the applications of DNA microarrays
within the drug discovery market segment.
-Histone Deacetylase Inhibitors: Redefining Pharmaceutical Approaches
to the Treatment of Cancer
http://www.bio.com/jump.jhtml?id=200021
The evolution of histone deacetylase (HDAC) research represents a
fascinating area of cellular biology, spanning early work demonstrating
the role of histone proteins in modulating chromatin plasticity and thus
transcriptional control. The number of HDAC enzyme subtypes has expanded
considerably over the past few years, offering opportunities for the
development of HDAC inhibitors with improved specificity. This report
overviews the concept of histone remodelling, early HDAC research and the
11 known human class I and class II HDACs, as well as the related sirtuin
family. LeadDiscovery, Dr. Chris Berrie and Dr. Victoria Richon have
collaborated to produce one of the most comprehensive reviews of HDAC
research, pharmaceutical opportunities, and current and future drug
development strategies published to date.
Click here to browse through our publications catalogue:
http://www.bio.com/jump.jhtml?id=200022
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7. FEATURED SOFTWARE
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Bio.com offers a very comprehensive selection of Life Science related
software. Check out these latest additions:
-BrainMaker Professional
http://www.bio.com/jump.jhtml?id=200023
BrainMaker Professional slashes development time, reduces trial-and-error
tedium, and creates networks that recognize patterns and predict better
than any other neural network system. Professional has all the features and
ease of use of standard BrainMaker plus the most advanced features available.
BrainMaker Professional v3 is the Advanced Neural Network Application
Development System for people who demand the most highly powered development
tools, most analysis functions, and greatest ease of use.
-HyperChem Release 7 for Windows CD-ROM Plus Boxed Book Set
http://www.bio.com/jump.jhtml?id=200024
HyperChem is a sophisticated molecular modeling environment that is known
for its quality, flexibility, and ease of use. HyperChem Release 7
incorporates even more powerful computational chemistry tools than ever
before, as well as newly incorporated modules, additional basis sets, new
drawing capabilities and more!
-Array Designer 2
http://www.bio.com/jump.jhtml?id=200025
DNA Microarray Software: Batch PCR primer design and hybridization probe
design tool for Windows. Supports many specialized needs like ORF studies
and SNP detection using primer extension. Can be used with DNA chip and
gene chip arrays.
Click here to browse through our software catalogue:
http://www.bio.com/jump.jhtml?id=200026
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Copyright (c) 2002 Bio Online, Inc. All rights reserved.
Received on 2002-08-14 - 07:13 GMT
This archive was generated by hypermail 2.2.0 : 2005-11-24 - 10:21 GMT