From:	"Bruce A. Luxon" <bruce "at@at" cosy.utmb.edu>
Date:	Fri, 21 Mar 1997 07:33:26 -0600
Subject:	Structural Biology and Virology Positions Available

Positions in Virology and Structural Biology

University of Texas Medical Branch at Galveston

* * * * * * * * * * * * * * * * * * * * * * *

Postdoctoral and research technician positions are available to
carry out structure-based design of antiviral agents directed
against cell attachment and replication of alphaviruses,
flaviviruses and arenaviruses.  This project, funded by the
Defense Advanced Research Projects Agency (DARPA; see Science,
275, pp. 744-746), provides unique opportunities to participate
in a highly focused interdisciplinary approach bringing together
internationally recognized structural biologists from the Sealy
Center for Structural Biology and virologists from the World
Health Organization Collaborating Center for Tropical Diseases.
Facilities include state-of-the-art Biosafety level 3
laboratories, automated sequencing and molecular biology imaging
equipment.

Instrumentation available for structural studies includes Varian
UNITYplus 750 (4 channel), 600 and wide-bore 400 MHz
spectrometers, Cray J90 supercomputer, SGI Power Challenge and
graphics workstations, MacScience imaging plate detectors and
rotating anode X-ray generators, and a Pharmacia DNA
synthesizer. We also have our own fully-equipped graphics and
multimedia preparation system.

Both postdoctoral (Ph.D. degree) and technician (BS or MS
degree) candidates are encouraged to apply for positions in the
following areas:

Structural and Molecular Biology:

1. Expression, purification and X-ray crystallography of viral
   molecules.

2. Drug development using phage display techniques.

3. Biomolecular NMR spectroscopy (protein and nucleic acid
   structures), backbone modified aptamer oligonucleotide
   synthesis, molecular biology, combinatorial chemistry,
   computational biology and computer-aided drug design.

4. Production, purification and testing of recombinant NFkB
   proteins, and testing of decoy oligonucleotides using
   recombinant NFkB proteins in vitro and in cell culture
   systems.

Structural Biology Faculty:

David G. Gorenstein  (david #*at*# nmr.utmb.edu)
Robert O. Fox  (fox (- at -) bloch.utmb.edu)
Bruce A. Luxon  (bruce (+ at +) nmr.utmb.edu)
Stanley J. Watowich  (watowich;at;bloch.utmb.edu)

Virology:

1. Assay development and testing of decoy oligonucleotides in
   animal systems.  Experience in tissue and virus culture,
   animal infections, cytokine bioassays and immunoasssays is
   required.

 2. Mapping of RNA packaging signals and other conserved
    sequence elements in alphavirus genomes; testing of decoy
    oligonucleotides in cell culture and animal models.
    Experience in molecular virology and animal infections is
    required.

Virology Faculty:

Judy F. Aronson  (jaronson "at@at" mspo6.med.utmb.edu)
Alan D. T. Barrett  (abarrett at.at mspo5.med.utmb.edu)
Norbert K. Herzog  (nherzog-0at0-mspo4.med.utmb.edu)
Robert E. Shope  (rshope #*at*# mspo6.med.utmb.edu)
Scott C. Weaver  (sweaver-: at :-marlin.utmb.edu)

Please send CV, statement of research interests and career
goals, and the names, addresses and telephone numbers of three
references to:

Dr. Robert E.  Shope, Department of Pathology,
University of Texas Medical Branch,
Galveston, Texas 77555-0609;
FAX (409) 747-2429;
Email: robert.shope "-at-" utmb.edu.

Further information can also be obtained by contacting me or any
of the faculty listed above.


--

*=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-*
*  Bruce A. Luxon, Ph.D                                                    *
*  Assistant Professor                                                     *
*  Sealy Center for Structural Biology                                     U
*  Dept. of Human Biological Chemistry & Genetics                          T
*  University of Texas Medical Branch                                      M
*  Galveston, TX   77555-1157                                              B
*                                                                          *
*  (409)747-6802; Fax (409)747-6850              http://www.hbcg.utmb.edu/ *
*  bruce - at - nmr.utmb.edu                            http://www.nmr.utmb.edu/  *
*=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-*


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