|
|
QCPE
THIS INFORMATION IS OBSOLETE AND IS PROVIDED ONLY FOR ITS HISTORICAL VALUE
Main / Catalog / Section11
|
QCMP075. pHENZY: Program to Conform the pH Dependence
of the Michaelis Parameters of Nonallosteric
Enzymes to Four Kinetic Schemes
by Fernando J. Vega-Catalan, Computer Science
Department, University of Ibadan, Ibadan,
Nigeria
The study of the pH dependence of the Km and
Vmax parameters of the Michaelis-Menten
equation provides valuable information about
enzymes. It can help in identifying the
kinetic scheme followed by the enzyme-
catalyzed reaction and in establishing the
ionization constants of the amino-acid chain
groups which determine the enzyme's activity.
This program fits the Km and Vmax versus pH
experimental profiles to four kinetic
mechanisms described by Tipton and Dixon.
The fit is obtained via a nonlinear
optimization search with starting values
generated by the program, which relieves the
user from having to enter a good initial
estimate for the nonlinear fit. The program
is menu driven and provides best-fit plots
and residual plots along with the best-fit
parameters and their uncertainties.
Borland TURBO PASCAL (v. 4.0 or later)
Lines of Code: 1675
|
Computational Chemistry List --- QCPE Main --- About This Site
|
